Effects of white ginseng on reducing stress and tension by enhancing default mode network connectivity: A randomized, double-blinded placebo-controlled clinical trial.

ABSTRACT:

Background

Recent research has increasingly focused on the potential role of white ginseng (Panax ginseng Meyer, PGC) in alleviating psychological conditions. This study aims to evaluate the efficacy and safety of PGC in reducing stress and tension over a 12-week period, employing a randomized, double-blind, placebo-controlled trial design.

Methods

A total of 86 participants reporting stress-related symptoms were randomized to receive either PGC (n = 42) or a placebo (n = 44). Stress levels were assessed using a composite stress index, which was derived from self-reported measures, skin conductance response, and heart rate variability, at baseline, week 6, and week 12. Additionally, resting-state functional magnetic resonance imaging was conducted at the same time poi

SUBMITTER: Shim Y 

PROVIDER: S-EPMC12629729 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature