Microbubble Contrast Agent Use During Invasive Coronary Microvascular Assessment.

ABSTRACT:

Background

Coronary microvascular function assessment with invasive Doppler-derived coronary flow reserve (CFR) has challenges related to Doppler signal quality, limiting clinical adoption. We investigated whether the use of ultrasound microbubble contrast agents can improve coronary flow signals and reduce measurement variability during invasive CFR measurement.

Methods

Participants underwent assessment of coronary flow velocity using a Doppler sensor-tipped coronary wire. Baseline signal quality was determined by expert clinicians, and signals were categorized into good or poor quality. Doppler quality was then assessed at predetermined time periods after administration of SonoVue (Bracco): baseline, first pass, and subsequent discrete 20-second time periods, following thi

SUBMITTER: Bahl R 

PROVIDER: S-EPMC12629735 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature