Ginsenoside Rb1 attenuates age-associated cognitive impairment by modulating oxidative stress and the SIRT1/eNOS/NO axis.

ABSTRACT:

Background

In traditional Chinese medicine ginseng, ginsenoside Rb1 (Rb1) is an active compound that has been shown to alleviate oxidative stress, modulate autophagy, and inhibit apoptosis. However, its role in the natural aging process remains unknown.

Aim

Investigate the role of Rb1 in natural aging and potential molecular mechanisms.

Methods

During eight weeks of treatment with Rb1, we administered low-dose (10 mg/kg·d) or high-dose (20 mg/kg·d) Rb1 to middle-aged (12-month-old) and aged (20-month-old) mice, and observed how changes in body weight and spatial learning were related to aging symptoms. Further, we measured oxidative stress-related markers and nitric oxide (NO) levels in the mice's hippocampal tissue after Rb1 treatment, and identified aging-related bi

SUBMITTER: Zhou B 

PROVIDER: S-EPMC12629746 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature