Risk of colorectal cancer by family history of both colorectal carcinomas and colorectal polyps: a nationwide cohort study.

ABSTRACT:

Background

The increased risk of colorectal cancer (CRC) associated with family history of both colorectal in situ or invasive carcinomas (Stage 0 to IV) and colorectal polyps is attributed solely to family history of CRC, resulting in an underestimation of the actual risk. We aimed to assess the association between overall and early-onset CRC (EOCRC) risk and family history of both colorectal carcinomas and polyps.

Methods

We conducted a nationwide cohort study leveraging Swedish family-cancer datasets with follow-up from 1964 to 2018. Standardized incidence ratios (SIRs) were calculated to estimate the risk of CRC and EOCRC among individuals with a family history of both colorectal polyps and carcinomas.

Results

We followed up 13,432,205 individuals for up to 54 yea

SUBMITTER: Hu Y 

PROVIDER: S-EPMC12629855 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature