Intranuclear paraspeckle-circular RNA TACC3 assembly forms RNA-DNA hybrids to facilitate MASH-related hepatocellular carcinoma growth in an m⁶A-dependent manner.

ABSTRACT:

Background

Metabolic dysfunction-associated steatohepatitis (MASH) is anticipated to become the leading cause of hepatocellular carcinoma (HCC). Accumulating evidence indicates that N6-methyladenosine (m⁶A)-modified circular RNAs (circRNAs) play key roles in tumor malignant progression. However, the precise molecular mechanisms by which circRNAs and their m⁶A modification regulatory networks respond to metabolic reprogramming, such as lipid overload stress, to drive malignant tumor progression in the context of MASH-related HCC remain unclear. This study aimed to investigate the role and regulatory network of m⁶A-modified circRNAs in MASH-related HCC.

Methods

Epitranscriptomic microarray and in situ hybridization assays were used to validate

SUBMITTER: Fu J 

PROVIDER: S-EPMC12629860 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature