CD9: Differential expression of normal bone marrow cellular components and leukemic myeloid blasts.

ABSTRACT:

Objective

Research on CD9 expression has been extensive in B lymphoblastic leukemia, with fewer studies focusing on acute myeloid leukemia (AML). We investigated the usefulness of CD9 in differentiating normal from abnormal myeloid progenitors, as well as expression in normal cell types and in AML.

Methods

Flow cytometry was used to assess the level of CD9 expression on normal and leukemic myeloid blasts and other normal bone marrow populations. Geometric mean fluorescence intensity levels and expression patterns were compared among cell types and AML subtypes.

Results

In normal subsets (n = 69), the level of CD9 expression was lowest in mature B cells, myeloid blasts, promyelocytes, and neutrophils, with intermediate expression in monocytes and highest in hematogones

SUBMITTER: Jasim A 

PROVIDER: S-EPMC12629872 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature