Precise Electrode Co-Alignment in Deep Brain Stimulation Fusing Neuroimaging and Electrophysiology.

ABSTRACT: We present a multimodal framework to improve the precision of electrode placement in deep brain stimulation (DBS) by fusing preoperative neuroimaging with intraoperative electrophysiology for accurate electrode co-alignment. The workflow integrates automated subthalamic nucleus (STN) segmentation from preoperative MRI using a two-step convolutional neural network (CNN), classification of microelectrode recordings (MER) with a transformer encoder and spatial co-alignment via a discrete optimisation procedure. Implemented as a 3D Slicer plugin, the pipeline enables real-time visualisation and interactive use during surgery. In validation on retrospective data of 17 trajectories from 12 Parkinson's disease patients, co-alignment reduced the mean lateral localisation error by 0.3 mm relative t

SUBMITTER: Varga I 

PROVIDER: S-EPMC12629890 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature