Jun Ginger Extract Improves Cold-Induced Asthma by Inhibiting Airway Inflammation via PI3K/AKT Pathway.

ABSTRACT: Jun Ginger (JG), a differently processed product from conventional dried ginger (CDG), lacks research on its health benefits. The study was designed to elucidate the bioactive components and therapeutic mechanisms of JG for cold-induced asthma (CA). In the present study, after the extraction methods of different processing products were optimized, the components of the aqueous-soluble extract of JG (JGAE) were identified by LC-TOF-MS. The protection of JGAE against CA was explored using CA mice and lipopolysaccharide (LPS)-injured BEAS-2B cells. After the metabolomics analysis, network pharmacology prediction and molecular docking test were performed, the effect of JGAE in regulating the phosphatidylinositol 3'-kinase/protein kinase B (PI3K/Akt) pathway was explored and validated by the PI

SUBMITTER: Wang X 

PROVIDER: S-EPMC12629912 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature