Prospective evaluation of circulating plasma thyroid hormones concentrations and breast cancer risk in the EPIC cohort.

ABSTRACT:

Background

Hyperthyroidism has been associated with increased risk of breast cancer and in vitro studies have shown that thyroid hormones may influence breast tumorigenesis. We aimed to study associations between prediagnostic circulating thyroid hormone concentrations and breast cancer risk.

Methods

We evaluated associations between breast cancer risk and circulating concentrations of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), fT3/fT4 ratio, and anti-thyroid peroxidase antibody (TPO-Ab) positivity, in plasma samples from 1518 invasive breast cancer cases (diagnosed between 2 and 14 years after blood collection) and 1518 matched controls from a case-control study nested in the European Prospective Investigation into Cancer and Nutri

SUBMITTER: His M 

PROVIDER: S-EPMC12629916 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature