Protecting double Holliday junctions ensures crossing over during meiosis.

ABSTRACT: Chromosomal linkages formed through crossover recombination are essential for the accurate segregation of homologous chromosomes during meiosis¹. The DNA events of recombination are linked to structural components of meiotic chromosomes². Imperatively, the biased resolution of double Holliday junction (dHJ) intermediates into crossovers^3,4 occurs within the synaptonemal complex (SC), the meiosis-specific structure that mediates end-to-end synapsis of homologues during the pachytene stage^5,6. However, the role of the SC in crossover-specific dHJ resolution remains unclear. Here we show that key SC components function through dependent and interdependent relationships to protect dHJs from aberrant dissolution into non-crossover products. Conditiona

SUBMITTER: Tang S 

PROVIDER: S-EPMC12629981 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature