Collective homeostasis of condensation-prone proteins via their mRNAs.

ABSTRACT: The concentration of proteins containing intrinsically disordered regions must be tightly controlled to maintain cellular homeostasis^1,2. However, mechanisms for collective control of these proteins, which tend to localize to membraneless condensates, are less understood than pathways mediated by membrane-bound organelles^3,4. Here we report 'interstasis', a homeostatic mechanism in which increased concentration of proteins within RNA-protein condensates induces the sequestration of their own mRNAs. The selectivity of interstatic mRNA capture relies on the structure of the genetic code and conserved codon biases, which ensure that similar multivalent RNA regions encode similar low-complexity domains. For example, arginine-enriched mixed charge domains (R-MCDs) tend to

SUBMITTER: Faraway R 

PROVIDER: S-EPMC12629991 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature