Feather-inspired janus interfaces with spatiotemporal ionic programming for diabetic wound infection control and regenerative healing.

ABSTRACT: Recalcitrant wounds, such as diabetic foot ulcers (DFUs), pose a significant challenge to current therapeutic options due to persistent exudate, high infection risk, and a complex pathological microenvironment. This necessitates a novel dressing that can simultaneously provide both a physical barrier and active biological intervention. Inspired by the feathers of waterfowl, we developed a hierarchically engineered Janus dressing (PPT@PG-BG) via electrospinning, which integrates a hydrophobic antibacterial outer layer with a hydrophilic inner layer for the spatiotemporally controlled release of therapeutic ions (Mg²⁺, Zn²⁺, and Ce³⁺). This "external defense and internal regulation" strategy effectively re-establishes immune-angiogenic homeostasis by activati

SUBMITTER: Huang C 

PROVIDER: S-EPMC12630035 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature