A self-locking conductive cardiac patch for immediate electrical integration with infarcted rat myocardium.

ABSTRACT: Myocardial infarction (MI) is the leading cause of human death. Conductive patches have emerged as a promising alternative for MI repair. However, due to the epicardium and the scar tissue blocking the electrical connection between the patch and the myocardium, the immediate and effective electrical integration of the patch with the host myocardium remains a great challenge. Here, we report a conductive barbed microneedle-integrated conductive patch (CBMN-CP). The microneedle can not only self-anchor robustly to the myocardium, but also penetrate the epicardium into the inner myocardium enabling patch to bridge non-infarcted myocardium across the infarcted area immediately and to re-establish the electrical pathways in the infarcted myocardium. The rat MI model experiments demonstrated CBM

SUBMITTER: Shan M 

PROVIDER: S-EPMC12630037 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature