Effects of gut microbiota interventions on patients with schizophrenia: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Schizophrenia (SCH) is a chronic psychiatric disorder characterized by disturbances in thought, emotion, perception, and behavior. Although gut microbiota interventions (e.g., probiotics, prebiotics, synbiotics, dietary modifications and fecal microbiota transplantation) have been widely applied in the treatment of SCH, the most effective intervention strategy remains uncertain.

Methods

By searching four databases, only randomized controlled trials (RCTs) were included to examine the impacts of gut microbiota interventions on SCH. The Cochrane risk-of-bias tool for randomized trials (RoB 2.0) was employed to assess the methodological quality of the included studies, RevMan5.4 was used for the meta-analysis, Stata 18 was used for sensitivity analysis, Engauge Dig

SUBMITTER: Ye N 

PROVIDER: S-EPMC12630112 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature