Modifying feeding protocols in critically ill patients based on a predictive model of feeding intolerance: protocol for a multicenter cluster randomized controlled trial (the mNEED study).

ABSTRACT:

Objectives

It remains unclear whether the modified nutrition protocol for critically ill patients (mNEED), based on the NOFI predictive model for feeding intolerance (FI), can reduce the incidence of FI and subsequently improve clinical outcomes.

Design

This is a multicenter, cluster-randomized controlled trial.

Setting

Ninety intensive care units (ICUs) across China.

Participants

A total of 2,250 critically ill patients initiating early enteral nutrition who meet the inclusion criteria.

Intervention

In addition to standard care, centers randomized to the intervention arm will implement nutritional therapy strictly according to the mNEED protocol.

Primary outcome measure

The primary outcome is the incidence of FI within the first 7 days of ICU adm

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12630114 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature