Prediction and quality evaluation of quality markers of <i>Gentiana scabra</i> Bunge. in treatment of liver injury.

ABSTRACT:

Introduction

Gentiana scabra Bunge. (GSB) has been demonstrated to exert nourishing effectson the liver and gallbladder. Notably, GSB extract has a marked therapeutic effect on liver injury (LI). However, the quality markers (Q-markers) of GSB associated with this effect remain unclear. Moreover, no study to date has evaluated the quality of GSB from different producing areas based on such Q-markers.

Methods

The aim of this study was to identify the Q-markers of GSB that define its therapeutic efficacy against liver injury. This was achieved through establishing HPLC fingerprints and conducting "small molecule-protein" interaction screening, followed by verification using in vitro cell experiments. Finally, the identified Q-markers were quantified to assess the

SUBMITTER: Liu J 

PROVIDER: S-EPMC12630122 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature