Post-traumatic epilepsy: bridging pathogenesis, diagnosis, and pharmacotherapeutic strategies.

ABSTRACT: Post-traumatic epilepsy (PTE)-affecting 2%-50% of traumatic brain injury (TBI) survivors with severity-dependent incidence-drives secondary neurodegeneration through elevated intracranial pressure (ICP), axonal injury, and neuroinflammatory cascades. While integrated risk stratification (e.g., cortical contusion, acute subdural hematoma on CT; blood-brain barrier disruption via dynamic contrast-enhanced MRI) enhances epileptogenesis prediction, mechanistic understanding of circuit reorganization underlying chronic hyperexcitability remains incomplete. Diagnosis integrates trauma history, seizure semiology, and multimodal monitoring (high-density EEG correlated with [18F] FDG-PET hypometabolism), yet evidence-based prophylaxis is confined to early PTE prevention. In this review, we will des

SUBMITTER: Yang X 

PROVIDER: S-EPMC12630123 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature