Nutritional considerations for designing ketogenic dietary interventions for people with Autosomal Dominant Polycystic Kidney Disease.

ABSTRACT: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a progressive genetic disease with few effective treatments available to slow the decline in kidney function. In ADPKD, there has been increasing interest in ketogenic diets, largely based on experimental data showing favorable effects on cyst growth and kidney function. High-quality clinical trials of sufficient duration using clinically relevant endpoints (estimated glomerular filtration rate [eGFR], kidney volume) are crucial to establish efficacy and safety in ADPKD. Although extensive reviews have been published about potential mechanisms of ketogenic diets to slow ADPKD progression, there is no guidance on how these diets should be designed to align with the unique clinical and nutritional needs of people with ADPKD. Potential s

SUBMITTER: Dawson J 

PROVIDER: S-EPMC12630169 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature