Circulating biomarkers of infection and endometrial cancer risk.

ABSTRACT:

Purpose

Incidence and mortality rates for endometrial cancer are rising. We need to better understand the etiology of this disease and identify new risk factors. We examined whether common genital infections are associated with endometrial cancer.

Methods

Using serum samples from The Polish Endometrial Cancer Study (443 cases, 443 controls), we measured antibodies against microbial antigens with a multiplex fluorescent bead-based assay. We estimated adjusted odds ratios (OR) and 95% confidence intervals (CI), comparing women with positive versus negative serology.

Results

Most antibodies were not associated with endometrial cancer overall, but seropositivity for Herpes simplex virus 2 was associated with low-grade tumors (OR 1.43 CI 1.02, 2.00). While increased risks

SUBMITTER: Michels KA 

PROVIDER: S-EPMC12630196 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature