Clinical outcomes of twice-weekly teriparatide acetate administration in osteoporosis.

ABSTRACT: W2TPD, a twice-weekly teriparatide administration regimen, was used on 163 patients. The continuation rate was 47%, with only one new fracture. Even after performing antiresorptive therapy, spine BMD increased significantly in the majority of groups. W2TPD demonstrated good efficacy and tolerability in a real-world sequential osteoporosis treatment model.

Purpose

Teriparatide is the most commonly administered daily, but there are also once-weekly and twice-weekly regimens. The former demonstrated high efficacy in increasing bone mineral density (BMD) and preventing new fractures; however, the continuation rate was reported to be low due to a high incidence of side effects. As a result, the twice-weekly teriparatide administration schedule (W2TPD) was created. In this study, we condu

SUBMITTER: Tominaga A 

PROVIDER: S-EPMC12630221 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature