Medullary sponge kidney: in-depth phenotyping for a better understanding of functional and structural abnormalities.

ABSTRACT:

Background

Medullary sponge kidney is an entity characterized by pre-calyceal dilatation of the renal tubules, whose pathophysiology is unknown. Tubular anomalies have been described, suggesting impaired medullary function. To better characterize these patients, tools for assessing medullary function and structure are needed. The latter can be evaluated with functional magnetic resonance imaging (fMRI), using blood-oxygen-level-dependent imaging, which quantifies tissue oxygenation, and diffusion-weighted-imaging and T1-mapping sequences which allow fibrosis assessment. The aim of this study was to deeply phenotype medullary sponge kidney patients.

Methods

We carried out fMRI, measured glomerular filtration rate (mGFR) by iohexol clearance, and metabolic assessment of urolit

SUBMITTER: Tournebize C 

PROVIDER: S-EPMC12630228 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature