Development of gastric mucosa-associated microbiota in autoimmune gastritis with neuroendocrine tumors.

ABSTRACT:

Background

Autoimmune gastritis (AIG) is a chronic atrophic gastritis that affects the gastric corpus, leading to achlorhydria, hypergastrinemia, and a precursor of neuroendocrine tumors (NETs). This study aimed to elucidate the underlying mechanisms of gastric NET formation in AIG by analyzing gastric mucosa-associated microbiota and host tissue-derived metabolite profiles.

Methods

A total of 19 patients diagnosed with AIG and 12 controls uninfected with Helicobacter pylori underwent gastric mucosal biopsies for microbiome analysis using next-generation sequencing with primers targeting the V3-V4 region of the 16S rRNA gene, and metabolome analysis using capillary electrophoresis time-of-flight mass spectrometry.

Results

Microbiome analysis revealed significantly red

SUBMITTER: Otani K 

PROVIDER: S-EPMC12630263 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature