Primary hyperoxaluria type 1 diagnosis in adult dialysis patients: prediction model assessment in a group of Italian patients.

ABSTRACT:

Background

To increase the diagnostic rate of primary hyperoxaluria type 1 (PH1) in the adult dialysis setting, a prediction model based on five readily available clinical parameters was recently developed and validated in an adult hemodialysis population. To further test the prediction model in clinical practice, this case series describes the retrospective application of the diagnostic algorithm in a group of adult dialysis patients with PH1 treated at different Italian nephrology centers.

Methods

Between January and May 2023, adult patients (≥ 18 years) undergoing chronic hemodialysis with a genetic diagnosis of PH1, followed at 14 Italian nephrology centers, were selected for the retrospective application of the prediction model.

Results

The presence of at least o

SUBMITTER: Ferraro PM 

PROVIDER: S-EPMC12630283 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature