Molecular mechanisms of bone metastasis in breast cancer based on transcriptomic and microbiomic analysis.

ABSTRACT:

Background

Bone metastasis (BM) in breast cancer affects patient prognosis, but its molecular mechanisms and relationship with the gut microbiome are not well understood. This study aims to explore gene expression and gut microbiome differences between BM and non-bone metastasis (BNM) patients, which could shed light on cancer progression and metastasis.

Methods

We utilized a multi-omics approach, integrating transcriptomic and microbiomic data. Bioinformatics techniques including differential expression analysis, functional enrichment, protein-protein interaction network analysis, and LDA effect size analysis were applied. We also constructed miRNA regulatory networks and gene-gene interaction networks to identify key genes and microbial functions involved in BM.

Results

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12630291 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature