Textbook oncologic outcomes in elderly patients undergoing neoadjuvant chemoradiotherapy and surgery for locally advanced rectal cancer: a multicenter study.

ABSTRACT: Standard treatment of locally advanced rectal cancer (LARC) involves neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME). However, in older patients, comorbidities and frailty may limit the feasibility of this approach. This study evaluates the incidence of Textbook Oncological Outcome (TOO), a composite quality metric in surgical oncology, in patients aged ≥ 70 years undergoing low anterior resection (LAR) for LARC after nCRT and identifies predictors of achieving this benchmark. We retrospectively analyzed 157 elderly patients with LARC treated by nCRT followed by LAR between 2011 and 2023 in three Italian tertiary centers. TOO was defined as R0 resection, no prolonged hospital stays (LOS < 11 days), no major complications (Clavien-Dindo < 3b), no 30-day read

SUBMITTER: Pulvirenti A 

PROVIDER: S-EPMC12630306 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature