Evaluating the dependence of ADC-fMRI on haemodynamics in breath-hold and resting-state conditions.

ABSTRACT: Apparent diffusion coefficient (ADC)-fMRI offers a promising functional contrast, capable of mapping neuronal activity directly in both grey and white matter. However, previous studies have shown that diffusion-weighted fMRI (dfMRI), from which ADC-fMRI derives, is influenced by blood-oxygen level dependent (BOLD) effects, leading to a concern that the dfMRI contrast is still rooted in neurovascular rather than neuromorphological coupling. Mitigation strategies have been proposed to remove vascular contributions while retaining neuromorphological coupling, by: i) analysing ADC timecourses calculated from two interleaved diffusion-weightings, known as ADC-fMRI; ii) using b-values of at least 200 s mm-2 ; and iii) using a sequence compensated for cross-terms with fluctuating background field

SUBMITTER: de Riedmatten I 

PROVIDER: S-EPMC12630321 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature