Circulating microRNA signatures as potential biomarkers differentiating diabetic, prediabetic, and healthy individuals.

ABSTRACT:

Introduction

Circulating microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and play key roles in metabolic diseases, including diabetes. This study aimed to identify circulating miRNA signatures linked to glycemic status, vitamin D deficiency, aspirin consumption, and platelet activity in individuals with type 2 diabetes, prediabetes, and healthy controls.

Methods

Plasma samples from 24 participants (14 with diabetes, 2 prediabetic, and 8 non-diabetic controls) were analyzed using next-generation sequencing to assess differences in miRNA expression.

Results

Although principal component analysis showed no group separation, pairwise testing identified 131 miRNAs that were significantly altered between the diabetic and control groups, as well as

SUBMITTER: Abu-Toamih Atamni HJ 

PROVIDER: S-EPMC12630337 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature