Macrophage Nogo-B Drives Liver Fibrosis.

ABSTRACT:

Background & aims

Liver fibrosis is characterized by sustained injury stress, chronic inflammation, and repeated cell death and repair, all of which promote the progression of end-stage liver diseases (eg, liver cirrhosis and carcinoma). As an endoplasmic reticulum-residential protein, Nogo-B strongly regulates macrophage function, but whether Nogo-B-decorated macrophages affect inflammation and progression during liver fibrosis is unclear. The purpose of our current study was to elucidate the roles of Nogo-B^high macrophages during liver fibrosis development.

Methods

The expression and distribution of Nogo-B were analyzed in clinical specimens and animal models. By utilizing myeloid-specific Nogo-B knockout (Nogo-B^mko) mice, the mechanism and functional

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12630339 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature