Childhood conduct problems, potential snares in adolescence, and problematic substance use in Brazil.

ABSTRACT: Childhood conduct problems are associated with problematic substance use in adulthood; however, little is known about what might explain these associations outside of high-income countries where the majority of research is conducted. Data were analyzed from 4599 young people from the 1993 Pelotas Birth Cohort in Brazil. The exposure was conduct problems (age 11 years). Outcomes included hazardous alcohol consumption and illicit drug use (age 22 years). Mediators included police arrest (by age 18 years), gang membership (ages 18 and 22 years), and school noncompletion (by age 22 years). We performed counterfactual mediation using the parametric g-computation formula to estimate the indirect effect via all three mediators simultaneously. After adjusting for confounders (including hyperactivi

SUBMITTER: Stocker F 

PROVIDER: S-EPMC12630428 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature