Exploring ASPN as a pan-cancer biomarker with a focus on gastric cancer.

ABSTRACT:

Background

Cancer remains a leading cause of mortality worldwide, posing a serious threat to public health. The ASPN protein has emerged as a key player in certain cancers; however, its precise mechanisms and regulatory roles are still not well-defined.

Methods

We explored the expression of ASPN and its prognostic significance across various cancers. Functional enrichment analyses were conducted using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). The association between ASPN expression and factors including immune cell infiltration, immune checkpoint genes, microsatellite instability (MSI), tumor mutational burden (TMB), drug sensitivity, promoter methylation, and tumor mutation types was examined. Finally, the function of ASPN in stomach adenoca

SUBMITTER: Feng Y 

PROVIDER: S-EPMC12630480 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature