Exploring the evolving role of apolipoproteins in oncology: global trends and emerging frontiers.

ABSTRACT:

Background

Metabolic reprogramming, especially lipid metabolism, is crucial in cancer progression and treatment resistance. Apolipoproteins are crucial targets for research as they regulate autophagy, oxidative stress, and chemoresistance. A systematic bibliometric and bioinformatics approach is necessary to identify trends and elucidate the molecular mechanisms linking apolipoproteins to cancer.

Methods

A systematic bibliometric analysis was conducted using the Web of Science Core Collection and PubMed. VOSviewer, CiteSpace, and the Bibliometrix R package were employed to analyze and visualize co-authorship networks, keyword trends, and other key metrics. Bioinformatics analysis integrated protein-protein interaction network construction, hub gene identification, and enrich

SUBMITTER: Tian D 

PROVIDER: S-EPMC12630503 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature