VDAC1 as prognostic marker and therapeutic target in lung adenocarcinoma: a study integrating bioinformatics and experimental validation.

ABSTRACT:

Background

Research on the expression and molecular mechanisms of voltage-dependent anion channels (VDACs) in lung adenocarcinoma (LUAD) remains limited.

Materials and methods

Multiple datasets were utilized to analyze VDACs expression in LUAD and investigate the clinical significance of VDACs-associated genes and signaling pathways. The database analysis results were further validated through cellular and animal experiments.

Results

The expression levels of VDAC1 and VDAC2 increase with advancing tumor stage. Subsequent survival analysis revealed that elevated mRNA expression of VDAC1 (HR = 1.6, log-rank P = 0.0015), VDAC2 (HR = 1.5, log-rank P = 0.0088), and VDAC3 (HR = 1.7, log-rank P = 0.0026) was significantly associated with shorter overall survival in LUAD pati

SUBMITTER: Cheng L 

PROVIDER: S-EPMC12630505 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature