Right Ventricular Myocardial Strain and Proteomic Analysis of Fetuses With Left Ventricular Hypoplasia: A Cross-Sectional Study.

ABSTRACT:

Background and aims

Decreased right ventricular (RV) function in fetuses with left ventricular hypoplasia (LVH) increases the risk of adverse outcome. This study aimed to quantitatively evaluate RV myocardial function prenatally in LVH, and explore the relevant mechanism from protein expression.

Methods

81 singleton fetuses diagnosed with LVH and 81 normal controls were retrospectively included. We used RV global longitudinal strain (RVGLS) derived from two-dimensional speckle tracking imaging to evaluate RV myocardial function and "XGboost" algorithm to select effective factors affecting RV myocardial function in fetuses with LVH. Bioinformatics analysis was performed for differentially expressed proteins between specimens with LVH and normal fetuses.

Results

In LVH

SUBMITTER: Ma J 

PROVIDER: S-EPMC12630553 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature