Natural killer cell-specific chimeric antigen receptor enhances CAR NK cell functions and anti-tumor activity.

ABSTRACT: Background: Unlike T cells, natural killer (NK) cells lack a dominant activating receptor analogous to the T cell receptor (TCR) that governs their activation. Whether chimeric antigen receptor (CAR) constructs engineered specifically for T cells can effectively drive NK cell activation remains unresolved. NK cells inherently possess non-specific recognition capacities and exert broad-spectrum cytotoxicity against diverse tumor targets. However, the complexity of receptor-ligand interactions between CAR NK cells and susceptible target cells has impeded efforts to delineate the specific functional contributions of individual CAR constructs. Methods: CAR NK cells were generated via electroporation. The murine B16 melanoma cell line was modified to express various target protein

SUBMITTER: Pan C 

PROVIDER: S-EPMC12630554 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature