Smurf1 promotes gastric cancer progression by regulating Axin2-dependent Wnt signaling pathway.

ABSTRACT: SMAD-specific E3 ubiquitin protein ligase 1 (Smurf1) is involved in various biological processes through targeting specific proteins for ubiquitin-dependent degradation. Emerging evidence has shown that Smurf1 functions as an oncogene in many types of human tumours, including gastric cancer (GC). We aimed to investigate the role of Smurf1 in regulating GC progression and reveal its underlying mechanism. Smurf1 expression was analyzed using two publicly available datasets. Additionally, it was assayed in 29 pairs of GC tissues and para-cancerous tissues using quantitative reverse transcriptase PCR (qRT-PCR). The biological roles of Smurf1 in GC cells were assessed in vitro and in a mouse xenograft model. The results showed that Smurf1 levels were significantly up-regulated in GC tissues com

SUBMITTER: Yu J 

PROVIDER: S-EPMC12630608 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature