Benchtop NMR urine metabolomics for diagnosing pulmonary tuberculosis.

ABSTRACT: Tuberculosis (TB) remains a major global health issue, especially in resource-limited settings, where rapid and accurate diagnosis is critical yet often lacking. Nuclear magnetic resonance (NMR)-based metabolomics has emerged as a promising tool for identifying disease-specific biomarkers. This study assessed the diagnostic potential of urinary metabolomics using high-resolution (HR-)NMR and benchtop NMR (bNMR) in Nigerian adults with presumed pulmonary TB, including individuals with and without HIV. Urine samples were analysed by HR-NMR and bNMR. Multivariate analysis was used to develop classification models based on confirmed TB status. Key discriminant metabolites were identified. In HIV-negative individuals, HR-NMR achieved 84% sensitivity and 86% specificity, while bNMR reached 83% a

SUBMITTER: Comella-Del-Barrio P 

PROVIDER: S-EPMC12630618 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature