Arginine modulates the pH, microbial composition, and matrix architecture of biofilms from caries-active patients.

ABSTRACT: The caries-preventive effects of arginine have been attributed to its impact on biofilm composition and pH. Recent in vitro studies suggest that arginine also affects the production of biofilm matrix components that contribute to virulence, but this mechanism has not been investigated clinically. This randomized, placebo-controlled, triple-blind, split-mouth in situ trial assessed arginine's impact on the microbial composition, matrix architecture, and microscale pH of biofilms from caries-active patients (N = 10). We also examined whether individual differences in the pH response to arginine were related to biofilm composition and matrix structure. Biofilms were grown for four days on carriers attached to intraoral splints. Three times daily, the biofilms were treated extraorally with suc

SUBMITTER: Del Rey YC 

PROVIDER: S-EPMC12630650 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature