Genetic risk score for cholesteatoma recurrence: using UK Biobank data toward more individualized patient management.

ABSTRACT:

Background

Cholesteatoma recurrence is relatively common and often requires repeat surgical interventions, imposing a significant burden on patients and healthcare systems. Although clinical factors such as age, disease aggressiveness, surgical technique, and surgeon experience influence recurrence risk, accurate prediction remains challenging. Genetic Risk Scores (GRS), which aggregate the effects of multiple genetic variants, offer a promising approach to individualized recurrence risk estimation.

Objective

To evaluate the contribution of specific genetic variants to cholesteatoma recurrence by constructing a GRS using data from the UK Biobank.

Methods

A systematic review of PubMed identified six genes previously associated with cholesteatoma recurrence: KGF (FGF7),

SUBMITTER: Vlastos IM 

PROVIDER: S-EPMC12630693 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature