Integrated analysis of Corylin from Psoralea Corylifolia inhibiting osteoporosis via MAPK pathway.

ABSTRACT: Corylin, a natural flavonoid from Psoralea corylifolia (PC), has shown promise in the treatment of osteoporosis (OP) but the underlying mechanisms are unclear. This study aims to elucidate these mechanisms using network pharmacology, bioinformatics, molecular docking and in vitro experiments. Firstly, 213 potential therapeutic targets and 44 key targets were identified. Using the CytoHubba plugin, we screened the top 10 hub genes, including MMP9, BCL2, PPARG, PTGS2 and TNF, and others. Secondly, we identified that the MAPK, HIF-1, and Ras signaling pathways were highly enriched through enrichment analysis. The high enrichment of the MAPK pathway was further validated through transcriptomic analysis. Additionally, molecular dynamic simulation verified the formation of stable complexes betwe

SUBMITTER: Liu N 

PROVIDER: S-EPMC12630715 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature