Risk factors and neurodevelopmental outcomes of post-neonatal seizures up to age three in very-low-birthweight infants based on a nationwide cohort.

ABSTRACT: We assessed the risk factors of post-neonatal anti-epileptic medications after neonatal intensive care unit discharge (PD-AED) and neurodevelopmental (ND) outcomes by age three in very-low-birth-weight infants (VLBWIs), with 7,292 VLBWIs born in 2013-2020 using the Korean Neonatal Network data. We assessed the risk factor of PD-AED and compared the risks for cerebral palsy (CP), blindness, deafness, and ND impairments between five groups: group 1, no seizure; group 2, neonatal seizure only; group 3, neonatal seizure + PD-AED before age three; group 4, neonatal seizure + PD-AED up to age three; group 5, PD-AED without neonatal seizure. By age three, 515 infants (7.1%) had seizures and 241 infants (3.8%) had PD-AED. Higher GA, intra-ventricular hemorrhage ≥ grade 3, post-hemorrhagic hydrocep

SUBMITTER: Kang H 

PROVIDER: S-EPMC12630783 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature