Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mild closed head injury.

ABSTRACT: Repeated mild closed head injury (rmCHI) is a significant public health concern, and this type of repetitive injury is garnering increasing attention, not least because of its increasing incidence in sports. The underlying neuroimmune mechanisms secondary to trauma that link rmCHI to cognitive impairment remain to be elucidated, and the contribution of the complement system to the pathological sequelae of this type of brain injury is unexplored. Here, using C57BL/6J mice, we established a repetitive 12-head impact model to investigate the neuroimmune and pathological processes that occur after rmCHI. We specifically studied the role of complement in pathology and cognitive impairment up to 21 days after the cessation of injury in a clinically relevant paradigm using the site-targeted compl

SUBMITTER: Mallah K 

PROVIDER: S-EPMC12630812 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature