PBMC proteome is altered in children with high body fat percentage.

ABSTRACT: Obesity in children is an increasing public health issue. Excess adipose tissue, especially in the form of visceral obesity, is associated with poorer cardiometabolic health, persistent low-grade inflammation and oxidative stress. Mass-spectrometry based analysis of peripheral blood mononuclear cells (PBMC) can reveal changes associated with dietary patterns, inflammatory diseases and obesity in adults. We aimed to identify proteomic dysregulations in PBMC of children with obesity, focusing on pathways linked to inflammation and metabolic dysfunction. We isolated cell lysate proteins from blood samples obtained from 71 children and adolescents (aged 5-18) with normal weight, overweight or obesity, measured body composition using bioelectrical impedance analysis, while protein abundances in

SUBMITTER: Petek M 

PROVIDER: S-EPMC12630839 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature