Identification and experimental validation of glycosylation related differentially expressed genes as diagnostic biomarkers in systemic lupus erythematosus.

ABSTRACT: As a heterogeneous autoimmune disorder, systemic lupus erythematosus (SLE) involves poorly characterized etiological mechanisms and disease pathways. While glycosylation's impact on immune homeostasis and disease pathogenesis has become a focal point in contemporary research, delineating the specific contribution of associated genes to SLE requires expanded investigation. This study uses bioinformatics methods to explore the potential diagnostic value of glycosylation-related differentially expressed genes (GRDEGs) in SLE and verify their differential expression in peripheral blood between patients and healthy individuals through RT-qPCR. Data were obtained from several GEO datasets, specifically GSE50772, GSE81622, and GSE20864. Through expression differential analysis, a total of 26 GRDE

SUBMITTER: Zheng C 

PROVIDER: S-EPMC12630927 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature