Gold-Dithiocarbamato Glycoconjugates as Potential Anticancer Agents: Design, Physico-Chemical Characterization, and In Vitro Biological Activity.

ABSTRACT: To develop new metal-based glycoconjugates as potential anticancer agents, three gold(III)-dithiocarbamato glycoconjugates of the type [Au^IIIBr₂(SSC-Inp-GlcN)] (Au3-5), their gold(I)-phosphine counterparts [Au^I(SSC-Inp-GlcN)(PPh₃)] (AuP3-5), and gold(I)-carbene analogs [Au^I(SSC-Inp-GlcN)(Et₂BzImy)] (AuC3-5) (Inp: isonipecotic moiety; GlcN: amino-glucose scaffold; Et₂BzImy: 1,3-diethylbenzimidazol-2-ylidene moiety), as well as the corresponding non-glycosylated counterparts (Au1-2, AuP1-2, and AuC1-2) bearing a terminal ester or amide function, are generated and characterized by means of several analytical techniques (FT-IR, ¹H-/¹³C-NMR, UV-Vis, X-ray crystallography). Their stability under ph

SUBMITTER: Pettenuzzo A 

PROVIDER: S-EPMC12631006 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature