Cognitive Impairment in Temporal Lobe Epilepsy: Alterations in the Basal Forebrain Cholinergic System.

ABSTRACT:

Objective

Temporal Lobe Epilepsy (TLE) often leads to cognitive decline. The Basal Forebrain Cholinergic System (BFCS), essential for memory processes, may play a critical role. This study investigates BFCS alterations, associated white matter tracts, and cognitive correlations in TLE patients.

Methods

We analyzed 100 unilateral TLE patients and 25 healthy controls. Neuropsychological assessments included the Wechsler Memory Scale-Revised and the Rey Complex Figure Test. Regions of interest (ROIs), such as the hippocampus, amygdala, and dorsolateral prefrontal cortex, were identified using the AAL3 atlas and SPM 8 Anatomy toolbox. BFCS tract integrity was assessed using FSL probabilistic tractography, focusing on FA and MD values.

Results

Both left TLE (LTLE) and righ

SUBMITTER: Shen B 

PROVIDER: S-EPMC12631018 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature