Caffeine exacerbates exercise-induced gut cell damage and is influenced by ADORA2A genotype but not CYP1A2 genotype: A preliminary study.

ABSTRACT: Endurance exercise may be associated with acute damage to intestinal epithelial cells. The effect of caffeine supplementation, and whether this is influenced by common genetic polymorphisms (ADORA2A: rs5751876 and CYP1A2: rs762551), is not currently known. Participants (n = 18 men and women) ingested caffeine (3 mg/kg body mass) or placebo 45 min before cycling (20 min at 70% maximal oxygen uptake followed by a 15-min performance time-trial). Plasma intestinal fatty acid binding protein (iFABP) was measured pre-supplementation, pre- and post-exercise. Four-way mixed ANOVAs revealed significant main effects of treatment, time, and treatment × time interaction (p < 0.05). Post hoc tests revealed a post-exercise increase in plasma [iFABP], which was greater with caffeine; and a trial × ADORA2

SUBMITTER: Davison G 

PROVIDER: S-EPMC12631023 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature