Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches.

ABSTRACT:

Objective

To identify contraindicated medications and corresponding target genes for migraine and its subtypes.

Method

Utilizing the Genome-Wide Association Studies (GWAS) for 14 medication-use categories from UK Biobank and GWAS for migraine and its subtypes from FinnGen, our study revealed potential contraindicated drugs for the chronic paroxysmal neurological disorder based on Mendelian randomization (MR). Then we applied the Transcriptome-wide association study (TWAS) within the framework of Omnibus Transcriptome Test using Expression Reference Summary data (OTTERS) and cross-referenced three drug databases to determine the targeted genes of the identified contraindicated medications. Moreover, Summary-data-based Mendelian Randomization (SMR) and INtegration of TWAS And

SUBMITTER: Wang N 

PROVIDER: S-EPMC12631026 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature