Association between point mutations of macrolide-resistant <i>Mycoplasma pneumoniae</i> and clinical antibiotic treatment efficacy: a meta-analysis.

ABSTRACT:

Background

The increasing macrolide resistance in Mycoplasma pneumoniae is mainly driven by mutations in the V domain of 23S rRNA (A2063G/A2064G), which impairs the efficacy of first-line treatment. Previous meta-analyses failed to distinguish between mutation subtypes or quantify age-specific susceptibility, blurring the clinical significance of different mutation burdens.

Objective

To quantify the differential impact of single mutation (A2063G) and double mutation (A2063G + A2064G) on core clinical outcomes and to dissect the age-adjusted effects between children and adults.

Methods

We searched PubMed, Web of Science, Embase, Scopus, and CNKI databases (up to June 2025). The Newcastle-Ottawa Scale was used to assess study quality. Random-effects models

SUBMITTER: Wang R 

PROVIDER: S-EPMC12631039 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature