Multi-omic analysis identifies biological processes underlying progressive interstitial lung disease in systemic sclerosis.

ABSTRACT: Systemic sclerosis (SSc) is a rare autoimmune connective tissue disorder, and its primary cause of mortality is interstitial lung disease (ILD). This study aimed to identify markers in patients with SSc that are associated with ILD progression. In total, 52 SSc patients and five healthy volunteers (HVs) were included. Patient plasma samples were available for measurement of soluble mediators by metabolomics, proteomics, and cytokine quantification. Gene expression profiling was performed on patients' whole blood and skin biopsies, and immunophenotyping was carried out on peripheral blood mononuclear cells. Comparisons were made between patients with progressive ILD, those with no ILD, and HVs. Our results confirm the involvement of pro-inflammatory mechanisms in SSc-related ILD, with eleva

SUBMITTER: Bouffette S 

PROVIDER: S-EPMC12631162 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature