Melanoma cells suppress mast cell function via a melanin-dependent mechanism.

ABSTRACT: Mast cells (MCs) have a well-established detrimental role in allergic conditions, but they can also impact diverse malignant conditions, including melanoma. To study the latter, previous studies have mainly evaluated how MCs can influence melanomas/melanoma cells. However, the inverse scenario, that is, whether melanoma/melanoma cells might impact MCs, has received less attention. Here we investigated this issue and show that melanoma cell-conditioned medium had a strong growth-inhibitory impact on MCs, which was attributed to inhibition of MC proliferation combined with induction of apoptosis. Further, our data indicate that such effects were attributable to melanin present in the melanoma cell-conditioned medium, as similar antiproliferative effects were seen in response to both free mel

SUBMITTER: Rabelo Melo F 

PROVIDER: S-EPMC12631163 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature